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I will realize the autonomous production of nucleotides that will soon break the monopoly of foreign technology within the year
Recently, it was reported that Shandong Shuangfeng Industrial Park has made significant progress in the development of high-purity monomer nucleotides. Shandong Shuangfeng Co., Ltd. has invested 65 million yuan to implement its proprietary enzymatic and separation technology, constructing a 100-ton-per-year production line for high-purity monomer nucleotides (Phase 1). The project is currently progressing smoothly and is expected to be completed and operational by the end of this year. Once launched, this will mark a major breakthrough for China's nucleotide industry, breaking the long-standing foreign technological monopoly and enabling domestic industrial production. This achievement will significantly reduce reliance on imports and have a profound impact on downstream sectors such as pharmaceuticals, food, agriculture, and health products.
Nucleotides, as deep-processing products of RNA, are widely used in medicine, food, agriculture, and other industries. For many years, the production technology for these compounds was dominated by a few countries, including the United States, Japan, South Korea, and Germany, which imposed a 30-year technological blockade on China. During the "Sixth Five-Year Plan" period, Chinese research institutions attempted to develop domestic nucleotide production, but commercial-scale manufacturing remained elusive. At that time, the annual output of single nucleotides in China was around 25 tons, with Shandong Shuangfeng accounting for 20 tons of that. Mononucleotide nucleotides are high-value products, with international prices reaching nearly $280,000 per ton. China imports approximately 180 tons annually, but due to the technological restrictions, all imported nucleotides are of food-grade quality, with purity below 90%. This has severely limited the growth of the nucleotide industry and its related sectors.
Shandong Shuangfeng Co., Ltd. has been at the forefront of nucleotide development in China. In June of this year, the company began construction on a 100-ton-per-year high-purity mononucleotide project. This initiative was designated as a National High-tech Industrialization Demonstration Project by the National Development and Reform Commission, receiving 6 million yuan in funding. Local governments also provided additional financial support to ensure the project’s success.
The project utilizes patented technology developed jointly by Shuangfeng and East China University of Science and Technology. This innovative process offers numerous advantages: the conversion rate of nucleotides can reach up to 95%, which is 15% higher than traditional methods; total yield has increased from 35% to 67%; product purity has risen from 90% to 98%; and production costs have been significantly reduced, with enzyme-related costs dropping from 15% to just 1.5% of total expenses. Additionally, the process eliminates waste gas, wastewater, and solid waste emissions. Unlike traditional methods that only allow production during spring, autumn, and winter, this new system enables continuous, large-scale production throughout the year.
Once fully operational, the project is expected to generate an additional 180 million yuan in annual sales revenue and contribute 28 million yuan in profit and taxes. This milestone marks a turning point for China’s nucleotide industry and signals a new era of self-reliance and technological advancement in this critical field.